Have you ever struggled with excess weight or obesity, longing for a solution that could truly help you shed those unwanted pounds and improve your overall health? If so, you’re not alone. Millions of people worldwide face similar challenges, seeking safe and effective weight management options1. Saxenda, an injectable prescription medication, may just be the answer you’ve been searching for.
Saxenda (liraglutide) is a groundbreaking treatment designed to help adults with excess weight (BMI ≥27) who have weight-related medical issues or obesity (BMI ≥30), as well as children aged 12-17 years with a body weight exceeding 132 pounds (60 kg) and obesity, to lose weight and maintain a healthier lifestyle123. But what makes Saxenda so unique, and how can it benefit those struggling with their weight?
Key Takeaways
- Saxenda is a prescription medication used for weight management in adults with excess weight or obesity, and in children aged 12-17 with obesity.
- It can help patients lose weight and maintain weight loss when used in combination with a reduced-calorie diet and increased physical activity.
- Saxenda has been shown to have both common and serious potential side effects, including nausea, diarrhea, and increased risk of thyroid tumors.
- Individuals with certain medical conditions or a history of thyroid cancer should not use Saxenda.
- Children using Saxenda may be at higher risk of low blood sugar and should be closely monitored.
What is Saxenda?
Saxenda is an injectable medication used for weight management in adults with obesity, as well as overweight adults with weight-related conditions4. It contains the active ingredient liraglutide, which belongs to a group of drugs called GLP-1 agonists4. Saxenda is approved for use in adults with a Body Mass Index (BMI) of 27 or higher who have weight-related medical problems, as well as those with a BMI of 30 or higher (obesity)5. For children aged 12-17 years, Saxenda is approved for use in those with a body weight above 132 pounds (60 kg) and obesity5.
Saxenda’s Active Ingredient and Usage
Saxenda contains the active ingredient liraglutide, which is a GLP-1 receptor agonist4. It is an injectable medication that should be administered subcutaneously in the abdomen, thigh, or upper arm4.
Saxenda’s Indications and Restrictions
Saxenda is indicated for use in adults with excess weight or obesity, as well as in children aged 12-17 years with a body weight above 132 pounds (60 kg) and obesity5. However, Saxenda should not be used with other GLP-1 receptor agonist medications, and its safety and efficacy have not been established when used with other prescription, over-the-counter, or herbal weight-loss products5.
| Saxenda Indications | Saxenda Restrictions |
|---|---|
| Adults with a BMI of 27 or higher who have weight-related medical problems | Should not be used with other GLP-1 receptor agonist medications |
| Adults with a BMI of 30 or higher (obesity) | Safety and efficacy not established when used with other weight-loss products |
| Children aged 12-17 years with a body weight above 132 pounds (60 kg) and obesity |
Who Should Not Use Saxenda?
Saxenda, a medication used for weight loss, is not suitable for everyone. It is essential to understand the contraindications and who should avoid using this drug6. Individuals with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) should not take Saxenda, as it has been associated with thyroid tumors in animal studies7. Additionally, pregnant women or those planning to become pregnant should not use Saxenda, as it may harm the unborn baby.
Severe allergic reactions to liraglutide, the active ingredient in Saxenda, or any of the other components of the medication are also contraindications for its use7. Furthermore, the safety and effectiveness of Saxenda have not been established for children under the age of 12 or for those aged 12 to 17 with type 2 diabetes7.
It is crucial for individuals considering Saxenda to discuss their medical history and any existing conditions with their healthcare provider to ensure it is the appropriate treatment option8. Saxenda should not be used with other weight-loss products, insulin, or GLP-1 receptor agonist medicines, as the safety and efficacy of such combinations are unknown8.
Staying informed about the contraindications and restrictions for Saxenda is essential to ensure safe and effective weight management. By understanding the individuals who should avoid this medication, healthcare providers can make informed decisions and provide the best possible care for their patients678.
Potential Side Effects of Saxenda
While Saxenda, a medication used for weight management, can be an effective treatment option, it’s important to be aware of its potential side effects9. Patients who are allergic to liraglutide or any ingredients in Saxenda should not use the medication9. Additionally, those with a history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) should refrain from taking Saxenda9.
Common Side Effects
The most common side effects of Saxenda in adults include nausea, diarrhea, constipation, vomiting, injection site reactions, low blood sugar (hypoglycemia), headache, fatigue, dizziness, and abdominal pain9. In children, additional common side effects may include fever and gastroenteritis9.
Serious Side Effects
Saxenda may also cause serious side effects, such as inflammation of the pancreas (pancreatitis), gallbladder problems, increased risk of low blood sugar in adults with type 2 diabetes, risk of low blood sugar in children without type 2 diabetes, increased heart rate, kidney problems, and serious allergic reactions9. Patients should contact their healthcare provider immediately if they experience any of these serious side effects.
| Side Effect | Incidence Rate |
|---|---|
| Nausea | 39.3% |
| Diarrhea | 20% |
| Constipation | 16% |
| Vomiting | 15.7% |
| Injection Site Reactions | 13.9% |
It’s crucial for patients to inform their healthcare provider about any pre-existing medical conditions or medications they are taking, as Saxenda may interact with other drugs and supplements10. Pregnant women should discontinue Saxenda to avoid potential harm to the unborn baby, and breastfeeding mothers should consult with their healthcare provider about the use of Saxenda and its potential effects on breast milk9.
“For more information about Saxenda, individuals can visit the manufacturer’s website at https://www.saxenda.com/ or contact them at 888-809-3942.”9
Boxed Warning: Risk of Thyroid Tumors
Saxenda, a medication used for weight management, carries a significant warning about the potential risk of thyroid tumors, including thyroid cancer11. In studies conducted on animals, Saxenda and other medications with a similar mechanism of action have been shown to cause thyroid tumors and thyroid cancer11. However, it remains unclear whether Saxenda will have the same effect on human patients11.
As a result of this potential risk, Saxenda should not be used by individuals who have a personal or family history of a specific type of thyroid cancer called medullary thyroid carcinoma (MTC) or a condition known as Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)11. Healthcare providers are advised to counsel patients about the possible risk of thyroid tumors associated with Saxenda treatment11.
Interestingly, recent research has shown that the overall incidence of thyroid cancer among users of GLP-1 receptor agonists, a class of medications that includes Saxenda, is relatively low12. In one study, only 76 out of 145,410 patients who used a GLP-1 agent developed thyroid cancer, corresponding to an incidence rate of 1.33 events per 10,000 person-years12. Additionally, the study found no elevated thyroid cancer risk among GLP-1 users compared to those using SGLT2 inhibitors12.
It’s important to note that the prescribing information for Saxenda has undergone recent major changes, including updates to the indications and usage section11. Patients and healthcare providers should carefully review the most up-to-date information to understand the potential risks and benefits of Saxenda treatment11.
While the boxed warning about the risk of thyroid tumors is a significant consideration, the overall safety and efficacy of Saxenda should be evaluated on an individual basis, taking into account each patient’s unique medical history and treatment goals11. Effective communication between patients and healthcare providers is crucial in navigating the complexities of Saxenda’s benefits and risks11.
Saxenda and Weight Management
Saxenda®, a prescription medication, is intended to be used as part of a comprehensive weight management plan that combines a reduced-calorie diet and increased physical activity13. The medication should not be used alone, but rather in conjunction with these lifestyle changes to help patients lose weight and maintain the weight loss13. Patients should work closely with their healthcare providers to develop a personalized diet and exercise plan that aligns with their individual needs and goals.
Incorporating Diet and Exercise
Saxenda is approved for use in adults with a body mass index (BMI) of 30 kg/m2 or greater, as well as overweight adults with a BMI of 27 kg/m2 or greater who have weight-related medical problems14. For pediatric patients aged 12 years and older, Saxenda can be used if their body weight is above 60 kg and their initial BMI corresponds to 30 kg/m2 or greater14.
To achieve the best results with Saxenda, it is essential to incorporate a reduced-calorie diet and increased physical activity13. Patients should work closely with their healthcare providers to develop a personalized plan that takes into account their individual needs, preferences, and goals13. Regular evaluation of weight loss progress is also recommended to determine the effectiveness of the Saxenda treatment14.
| Saxenda for Weight Loss | Saxenda for Weight Management |
|---|---|
| Saxenda is approved for use in adults with a BMI of 30 kg/m2 or greater14. | Saxenda is also indicated for overweight adults with a BMI of 27 kg/m2 or greater who have weight-related medical problems14. |
| Saxenda should be combined with a reduced-calorie diet and increased physical activity to achieve weight loss13. | Saxenda should be combined with a reduced-calorie diet and increased physical activity to maintain weight loss13. |
| Patients should work closely with their healthcare providers to develop a personalized diet and exercise plan13. | Regular evaluation of weight loss progress is recommended to determine the effectiveness of Saxenda treatment14. |
By incorporating a reduced-calorie diet and increased physical activity, patients can maximize the benefits of Saxenda and achieve their weight management goals13. This comprehensive approach, under the guidance of a healthcare provider, is crucial for successful and sustainable weight loss13.
How to Use Saxenda
Saxenda, a prescription medication for weight management, is administered as a subcutaneous injection15. To use Saxenda effectively, patients should rotate the injection site with each dose, typically in the abdomen, thigh, or upper arm, to reduce the risk of developing lumps under the skin (cutaneous amyloidosis)15. Saxenda should not be injected into a vein or muscle15.
The usual starting dose of Saxenda is 0.6 mg once per day, which can be increased stepwise to the recommended dose of 3.0 mg once a day15. Patients should follow the instructions for use provided with the medication and consult their healthcare provider if they have any questions or concerns about administering Saxenda15.
- Saxenda is used for weight loss in adults aged 18 years or older15.
- Saxenda should be used with a reduced-calorie diet and increased physical activity15.
- Saxenda is prescribed to adults with a Body Mass Index (BMI) of 30 or more (obese), or a BMI of 27 or more and less than 30 (overweight) with weight-related health problems15.
- Weight loss typically starts within 2 weeks of Saxenda treatment and continues for 9 to 12 months15.
It is essential for patients to strictly follow the prescribed dosage instructions for Saxenda to ensure its effectiveness and safety16. Changing the Saxenda dosage without medical advice should be avoided, as it can lead to serious adverse effects16.
| Saxenda Dosage Information | Details |
|---|---|
| Strength | 6 mg/mL16 |
| Maximum Dosage | 3 mg per day16 |
| Starting Dosage | 0.6 mg per day for adults16 |
| Dosage Increase Schedule |
|
| Pen Lifespan | Each Saxenda pen can be used for up to 30 days before being discarded16. |
Proper disposal of the Saxenda pen after 30 days, even if there is remaining medication inside, is advised16. The importance of accessible drug labels and containers for Saxenda use is highlighted, in braille, large print, or scannable formats16.
Precautions Before Taking Saxenda
Before initiating Saxenda17 treatment, it is crucial for patients to disclose their complete medical history to their healthcare providers. This includes any issues with the stomach, pancreas, kidneys, or liver, as well as a history of depression, suicidal thoughts, or other mental health concerns17. Patients should also inform their healthcare team if they are breastfeeding or plan to do so, as it is unknown whether Saxenda passes into breast milk17.
Medical Conditions to Disclose
Patients must make their healthcare providers aware of all their current medications, including prescription, over-the-counter, vitamins, and herbal supplements. Saxenda18 can interact with certain drugs, potentially affecting their effectiveness or causing unexpected effects. This is particularly important for individuals taking diabetes medications, such as insulin or sulfonylureas18.
Medication Interactions
Saxenda18 may have interactions with various medications, including antidepressants, GLP-1 receptor agonists, insulin, sulfonylureas, bismuth subsalicylate, and clarithromycin. These interactions can increase the risk of low blood sugar as a side effect18. Additionally, Saxenda is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)19.
It is crucial for patients to disclose all their medical conditions and medications to their healthcare providers before starting Saxenda treatment to ensure the safe and effective use of this weight loss medication171819.
“Saxenda is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).”19
saxenda
Saxenda is a prescription medication approved by the FDA for weight management in adults and children aged 12-17 with obesity20. It is the brand name for the active ingredient liraglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist20. Unlike other weight loss drugs, Saxenda is not available in a generic form and can only be obtained with a valid prescription20.
Saxenda is indicated for adult patients with a body mass index (BMI) of 30 kg/m² or greater (obese) or 27 kg/m² or greater (overweight) who have at least one weight-related comorbid condition, such as hypertension, type 2 diabetes, or dyslipidemia21. For pediatric patients aged 12 and older, Saxenda can be used if their body weight is above 60 kg (132 lbs) and their BMI corresponds to 30 kg/m² or greater for adults (obese) by international standards21.
It’s important to note that Saxenda should not be used in combination with other liraglutide-containing products or any other GLP-1 receptor agonists21. Additionally, patients with a personal or family history of medullary thyroid carcinoma (MTC), Multiple Endocrine Neoplasia syndrome type 2 (MEN 2), or serious hypersensitivity reactions to liraglutide should not use Saxenda21.
The most common side effects reported in at least 5% of patients using Saxenda include nausea, diarrhea, constipation, vomiting, injection site reactions, headache, hypoglycemia, dyspepsia, fatigue, dizziness, abdominal pain, increased lipase, upper abdominal pain, pyrexia, and gastroenteritis21. Despite these potential side effects, Saxenda has been recognized as an effective weight loss treatment option that helps with long-term weight management in people with obesity and certain individuals who are overweight20.
“Saxenda is an FDA-approved prescription medication that can help with weight loss and long-term weight management in adults and children with obesity.”
Administering Saxenda Injections
Saxenda® (liraglutide) is an injectable prescription medication used for chronic weight management in adults with obesity (BMI ≥30 kg/m²) or overweight (BMI ≥27 kg/m²) with at least one weight-related condition, as well as in children aged 12 and older with a body weight above 132 pounds (60 kg) and obesity1922.
To administer Saxenda, patients should inject the medication subcutaneously, meaning into the fatty tissue just under the skin, typically in the abdomen, thigh, or upper arm. It’s important to rotate the injection site with each dose to reduce the risk of developing lumps under the skin. Saxenda should never be injected into a vein or muscle19.
Patients should follow the detailed instructions for use provided with the Saxenda medication and consult their healthcare provider if they have any questions or concerns about administering the injections properly. Proper administration is crucial for ensuring the effectiveness and safety of Saxenda treatment19.
| Saxenda Injection Instructions |
|---|
|
Following the proper how to inject saxenda and saxenda injection instructions is essential for ensuring the medication’s effectiveness and minimizing the risk of side effects. Patients should work closely with their healthcare provider to ensure they are administering Saxenda correctly and addressing any concerns that arise1922.
Monitoring During Saxenda Treatment
Patients taking Saxenda, a prescription medication for weight management, require close monitoring by their healthcare providers23. This is especially important for potential side effects such as changes in heart rate, low blood sugar (hypoglycemia), and kidney problems23.
Patients with type 2 diabetes who are also taking medications to manage their condition, like insulin or sulfonylureas, may have an increased risk of low blood sugar23. These individuals should have their blood sugar levels checked regularly while using Saxenda23. All patients should check their blood sugar before starting Saxenda and continue monitoring it during treatment23.
| Metric | Saxenda Patients | Placebo Patients |
|---|---|---|
| Reported Suicidal Ideation | 9 (0.3%) out of 3,384 | 2 (0.1%) out of 1,941 |
| Suicide Deaths in Pediatric Trials | 1 (0.8%) out of 125 | N/A |
Additionally, healthcare providers should monitor patients for potential adverse reactions to Saxenda, such as nausea, diarrhea, constipation, vomiting, injection site reactions, headache, and hypoglycemia, each reported in ≥5% of patients23. Serious side effects like acute pancreatitis, acute gallbladder disease, hypoglycemia, and renal impairment have also been observed in Saxenda users23.
Physicians should also monitor patients for changes in resting heart rate, as Saxenda has been associated with23 mean increases of 2 to 3 beats per minute23. Serious hypersensitivity reactions, including anaphylaxis and angioedema, have been reported in patients treated with Saxenda23.
Overall, close monitoring is essential for patients using Saxenda to ensure their safety and optimize the benefits of this weight management medication232425.
Addressing Nausea with Saxenda
Nausea is a common side effect experienced by patients taking Saxenda, often occurring at the beginning of treatment26. While this can be challenging, there are steps individuals can take to manage this side effect and continue their weight loss journey with Saxenda.
One of the most effective strategies is to eat smaller, more frequent meals27. Avoiding rich or spicy foods and staying hydrated by sipping water frequently can also help alleviate nausea27. If nausea persists or becomes severe, it’s crucial for patients to contact their healthcare provider, as nausea can sometimes be a symptom of more serious side effects, such as pancreatitis or kidney problems26.
Clinical trials have reported that nearly 40% of adults taking Saxenda experience nausea, often beginning within a few days of increasing the dose27. However, this side effect typically improves within a few days as the body adjusts to the medication26.
While nausea can be an unpleasant experience, it’s important for patients to persist with Saxenda treatment. With the right management strategies and close communication with their healthcare provider, many individuals have been able to successfully navigate this side effect and achieve their weight loss goals2726.
In addition to nausea, other common side effects of Saxenda include diarrhea, which affects around 20% of users27, and constipation, which can be managed by consuming 25-30 grams of fiber daily27. Vomiting may also occur, particularly if nausea is present, but it typically improves within a few days27.
It’s important for patients to be aware of the potential side effects of Saxenda and to communicate openly with their healthcare provider about any concerns or challenges they may be experiencing. With the right support and management strategies, many individuals have been able to successfully navigate the side effects and achieve their weight loss goals2726.
| Side Effect | Percentage of Saxenda Users Affected |
|---|---|
| Nausea | 40%27 |
| Diarrhea | 20%27 |
| Constipation | Managed by 25-30 grams of fiber daily27 |
| Vomiting | Typically improves within a few days27 |
“Nausea can be a common side effect, but with the right strategies, patients can manage it and continue their weight loss journey with Saxenda.”
Risk of Allergic Reactions
Saxenda, a medication used for weight loss, may pose a serious risk of allergic reactions in some patients28. Potential symptoms of a severe allergic reaction can include swelling of the face, lips, tongue, or throat, fainting or dizziness, rapid heartbeat, difficulty breathing or swallowing, and severe rash or itching28. If a patient experiences any of these signs, they should immediately stop using Saxenda and seek urgent medical attention28.
Allergic reactions to Saxenda were described as rare in clinical trials, but these reactions can manifest with symptoms such as skin rash, itching, swelling, and difficulty breathing29. Before starting treatment with Saxenda, healthcare providers may evaluate the patient’s health history, including any allergic reactions to the drug or its components, to ensure safe use29.
Saxenda carries a boxed warning for the risk of thyroid cancer, which emphasizes the severity of this potential side effect29. For individuals with a history of thyroid tumors, cancer, or certain thyroid conditions, Saxenda may not be recommended due to the risk of exacerbating these conditions29.
Liraglutide, the active ingredient in Saxenda, has been shown to cause dose-dependent and treatment-duration-dependent thyroid C-cell tumors in rats and mice30. Saxenda is contraindicated for patients with a personal or family history of medullary thyroid carcinoma (MTC) and Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)30.
In cases where gastroparesis is a concern, Saxenda may not be suitable due to its potential to cause the condition known for delaying stomach emptying29.
Depression or suicidal thoughts have been reported in rare cases during Saxenda treatment, especially in individuals with a history of mental health issues29. This risk factor is essential to consider before prescribing Saxenda.
It is crucial for patients to be aware of the potential risks and to report any serious side effects to their healthcare provider immediately. By understanding the possible allergic reactions and taking appropriate precautions, patients can safely manage their weight with Saxenda while minimizing the risk of adverse events283029.
Safety Information for Children and Adolescents
Saxenda®, a medication used for weight loss, is approved for use in children aged 12-17 years with a body weight above 132 pounds (60 kg) and obesity31. However, the safety and efficacy of Saxenda® in children under 12 years of age have not been established31. Patients and their caregivers should closely monitor children and adolescents taking Saxenda® for potential side effects, such as low blood sugar, and report any concerns to their healthcare provider31.
According to the Centers for Disease Control and Prevention, 20% of individuals aged 12-19 years are considered obese32. In a 56-week study, Saxenda® was evaluated in 251 patients aged 12 to 17 with a BMI ≥ 30 kg/m2 or at the 95th percentile or greater for their age and sex32. Patients treated with Saxenda® had an average 0.23 reduction in their BMI SDS, while those on placebo had no reduction32. Additionally, patients on Saxenda® lost an average of 2.65% of their body weight, whereas those on placebo gained an average of 2.37%32.
However, the use of Saxenda® in children and adolescents is not without potential risks. Hypoglycemia (low blood sugar) occurred in 15% of patients on Saxenda®, compared to 4% on placebo32. Furthermore, one case of suicide was reported in the Saxenda® treatment group, though it was part of the pediatric clinical trial32. Common adverse reactions in children and adolescents using Saxenda® include gastrointestinal side effects, dizziness, fever, and a higher incidence of low blood sugar compared to the placebo group32.
Patients and their caregivers should be vigilant in monitoring for various potential adverse effects, such as pancreatitis, acute gallbladder disease, heart rate increase, kidney impairment, and hypersensitivity reactions, when using Saxenda® for weight management in children and adolescents32.
In conclusion, Saxenda® can be a useful tool for weight loss and maintenance in children and adolescents aged 12-17 with obesity, but its use requires close monitoring and careful consideration of the potential risks and benefits3132.
Saxenda for Type 2 Diabetes and Weight Loss
While Saxenda is not indicated for the treatment of type 2 diabetes, it may be used as part of a comprehensive weight management plan for adults with excess weight or obesity who also have type 2 diabetes33. Patients with type 2 diabetes who are taking Saxenda should be monitored closely, as there is a potential increased risk of low blood sugar, and their diabetes medications may need to be adjusted accordingly33.
Saxenda and its active ingredient, liraglutide, are approved by the FDA for long-term weight loss in adults with obesity or a BMI of 27 kg/m2 or greater with weight-related conditions33. In contrast, Victoza, another liraglutide-containing product, is approved for the treatment of type 2 diabetes in adults and children, as well as to reduce cardiovascular risks33.
Clinical trials have shown that Saxenda is more effective for weight loss than Victoza, likely due to its higher dosage regimen of 3 mg once daily compared to Victoza’s dosages of 0.6 mg, 1.2 mg, or 1.8 mg daily33. Both Saxenda and Victoza share common side effects, such as upper respiratory tract infections and back pain, but they also have unique side effects33.
| Characteristic | Saxenda | Victoza |
|---|---|---|
| Active Ingredient | Liraglutide | Liraglutide |
| Dosage | 3 mg once daily | 0.6 mg, 1.2 mg, or 1.8 mg daily |
| Approved Indications | Long-term weight loss in adults with obesity or BMI ≥27 kg/m2 with weight-related conditions | Type 2 diabetes treatment in adults and children, cardiovascular risk reduction |
| Pricing (1-month supply) | Approximately $1,19434 | Varies based on dosage and insurance coverage |
| Common Side Effects | Upper respiratory tract infections, back pain, nausea (39%)34, diarrhea or constipation (20%)34, vomiting (15%)34 | Upper respiratory tract infections, back pain |
| Discontinuation Rate | Approximately 10%34 | N/A |
| Average Weight Loss | 8.9 to 13.3 lbs (4 to 6 kg) in one year34 | N/A |
| 5% Weight Loss Achieved | Over 50% of patients34 | N/A |
| 10% Weight Loss Achieved | 25% to 33% of patients34 | N/A |
Both Saxenda and Victoza carry a boxed warning from the FDA for the risk of thyroid tumors and have restrictions based on past medical conditions33. Patients should not switch between Saxenda and Victoza without medical advice due to their distinct approved uses33.
In conclusion, while Saxenda is not indicated for the treatment of type 2 diabetes, it may be a useful weight loss option for adults with type 2 diabetes and excess weight or obesity, as part of a comprehensive weight management plan. Patients should work closely with their healthcare providers to monitor their condition and adjust their diabetes medications as needed33.
Conclusion
Saxenda, a prescription medication containing the active ingredient liraglutide, has emerged as an effective weight management option for adults with excess weight or obesity, as well as children aged 12-17 years with obesity. Clinical studies have shown that liraglutide can consistently result in a 4 to 6 kg weight loss in patients with obesity, and a greater proportion of patients achieved at least 5% and 10% weight loss compared to placebo35.
However, patients should be aware of the potential side effects associated with Saxenda, including the risk of thyroid tumors. It is crucial for individuals considering Saxenda to work closely with their healthcare providers to manage their treatment and monitor for any safety concerns35. Additionally, Saxenda should be used in conjunction with a reduced-calorie diet and increased physical activity to help patients lose weight and maintain the weight loss35.
The prevalence of overweight and obesity in Canada and globally remains a significant public health concern, with over 4 million people dying annually due to these conditions36. Medication options like Saxenda can play a role in addressing this issue, but they should be used as part of a comprehensive approach that also includes lifestyle modifications36. Overall, Saxenda offers a valuable tool for healthcare providers and patients in the ongoing battle against the challenges of excess weight and obesity.
FAQ
What is Saxenda?
Saxenda (liraglutide) is an injectable prescription medication used for weight management in adults with excess weight (BMI ≥27) who also have weight-related medical problems or obesity (BMI ≥30), and in children aged 12-17 years with a body weight above 132 pounds (60 kg) and obesity. Saxenda should be used in combination with a reduced-calorie diet and increased physical activity to help patients lose weight and maintain the weight loss.
What are Saxenda’s indications and restrictions?
Saxenda is indicated for use in adults with a BMI of 27 or higher who have weight-related medical problems, as well as those with a BMI of 30 or higher (obesity). For children aged 12-17 years, Saxenda is approved for use in those with a body weight above 132 pounds (60 kg) and obesity. Saxenda should not be used with other GLP-1 receptor agonist medications, and its safety and efficacy have not been established when used with other prescription, over-the-counter, or herbal weight-loss products.
Who should not use Saxenda?
Saxenda should not be used by individuals who have a personal or family history of medullary thyroid carcinoma (MTC) or a rare condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Additionally, Saxenda is contraindicated in patients who have had a serious allergic reaction to liraglutide or any of the other ingredients in the medication. Saxenda should also not be used by pregnant women, as it may harm the unborn baby.
What are the potential side effects of Saxenda?
The most common side effects of Saxenda in adults include nausea, diarrhea, constipation, vomiting, injection site reactions, low blood sugar (hypoglycemia), headache, fatigue, dizziness, and abdominal pain. In children, additional common side effects include fever and gastroenteritis.
What are the serious side effects of Saxenda?
Saxenda may also cause serious side effects, such as inflammation of the pancreas (pancreatitis), gallbladder problems, increased risk of low blood sugar in adults with type 2 diabetes, risk of low blood sugar in children without type 2 diabetes, increased heart rate, kidney problems, and serious allergic reactions. Patients should contact their healthcare provider immediately if they experience any of these serious side effects.
What is the boxed warning for Saxenda?
Saxenda has a boxed warning regarding the potential risk of thyroid tumors, including thyroid cancer. In studies with rats and mice, Saxenda and other medications that work similarly to Saxenda have been shown to cause thyroid tumors, including thyroid cancer. It is unknown if Saxenda will cause thyroid tumors or a specific type of thyroid cancer called medullary thyroid carcinoma (MTC) in humans.
How is Saxenda used for weight management?
Saxenda is intended to be used as part of a comprehensive weight management plan that includes a reduced-calorie diet and increased physical activity. The medication should not be used alone, but rather in combination with these lifestyle changes to help patients lose weight and maintain the weight loss.
How is Saxenda administered?
Saxenda is administered as a subcutaneous injection, meaning it is injected into the skin, typically in the abdomen, thigh, or upper arm. Patients should rotate the injection site with each dose to reduce the risk of developing lumps under the skin (cutaneous amyloidosis). Saxenda should not be injected into a vein or muscle.
What precautions should be taken before starting Saxenda?
Before starting Saxenda, patients should inform their healthcare providers about all of their medical conditions, including any problems with their stomach, pancreas, kidneys, or liver, as well as any history of depression, suicidal thoughts, or other mental health issues. Patients should also let their healthcare providers know about all the medications they are currently taking, as Saxenda can interact with certain drugs.
Is Saxenda a generic medication?
Saxenda is a brand-name prescription medication and is not available in a generic form. It can only be obtained through a prescription from a healthcare provider.
How should patients monitor their condition while taking Saxenda?
Patients taking Saxenda should be monitored by their healthcare providers, particularly for potential side effects such as changes in heart rate, low blood sugar (hypoglycemia), and kidney problems. Patients with type 2 diabetes who are also taking medications to treat their diabetes, such as insulin or sulfonylureas, may have an increased risk of low blood sugar and should have their blood sugar levels checked regularly.
How can patients manage nausea associated with Saxenda?
To help manage nausea, patients can try eating smaller, more frequent meals, avoiding rich or spicy foods, and staying hydrated by sipping water frequently. If nausea persists or becomes severe, patients should contact their healthcare provider, as nausea can sometimes be a symptom of more serious side effects.
What are the risks of allergic reactions with Saxenda?
Saxenda may cause serious allergic reactions in some patients. Symptoms of a serious allergic reaction can include swelling of the face, lips, tongue, or throat, fainting or dizziness, rapid heartbeat, difficulty breathing or swallowing, and severe rash or itching. Patients should stop using Saxenda and seek immediate medical attention if they experience any signs of a serious allergic reaction.
Is Saxenda approved for use in children and adolescents?
Saxenda is approved for use in children aged 12-17 years with a body weight above 132 pounds (60 kg) and obesity. The safety and efficacy of Saxenda in children under 12 years of age have not been established. Patients and their caregivers should closely monitor children and adolescents taking Saxenda for potential side effects, such as low blood sugar, and report any concerns to their healthcare provider.
Can Saxenda be used to treat type 2 diabetes?
Saxenda is not indicated for the treatment of type 2 diabetes, but it may be used in adults with excess weight or obesity who also have type 2 diabetes as part of a comprehensive weight management plan. Patients with type 2 diabetes who are taking Saxenda should be monitored closely for the potential increased risk of low blood sugar, and their diabetes medications may need to be adjusted.
Source Links
- https://www.saxenda.com/ – Prescription Weight-Loss Medicine | Saxenda® (liraglutide) injection 3mg
- https://www.saxenda.com/about-saxenda/dosing-schedule.html – Dosing Schedule for Saxenda® | Saxenda® (liraglutide) injection 3mg
- https://www.saxenda.com/about-saxenda/how-it-works.html – How Saxenda® Works | Saxenda® (liraglutide) injection 3mg
- https://www.healthline.com/health/drugs/saxenda – Saxenda Injection: Side Effects, Dosage, Cost, and More
- https://www.saxenda.com/about-saxenda.html – Saxenda® Weight-Loss Medication | Saxenda® (liraglutide) injection 3mg
- https://www.saxenda.com/support-and-resources/faqs.html – Frequently Asked Questions | Saxenda® (liraglutide) injection 3mg
- https://www.saxenda.com/support-and-resources.html – Saxenda® Information & Resources | Saxenda® (liraglutide) injection 3mg
- https://www.saxenda.com/content/dam/obesity/saxenda/pdfs/patient_brochure.pdf – PDF
- https://www.webmd.com/drugs/2/drug-168195/saxenda-subcutaneous/details – Saxenda: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing – WebMD
- https://www.mayoclinic.org/drugs-supplements/liraglutide-subcutaneous-route/side-effects/drg-20073828?p=1 – Liraglutide (Subcutaneous Route) Side Effects
- https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/206321s007lbl.pdf – LABEL
- https://www.medpagetoday.com/endocrinology/thyroid/109609 – Study Assuages Thyroid Cancer Fears With GLP-1 Receptor Agonists
- https://www.saxenda.com/about-saxenda/weight-loss-with-saxenda.html – Benefits of Weight-Loss Medications | Saxenda® (liraglutide) injection 3mg
- https://www.drugs.com/saxenda.html – Saxenda for Weight Loss, Dosage & Side Effects – Drugs.com
- https://www.medsafe.govt.nz/consumers/cmi/s/saxenda.pdf – PDF
- https://www.medicalnewstoday.com/articles/drugs-saxenda-dosage – Saxenda dosage: Form, strength, how to use, and more
- https://www.mayoclinic.org/drugs-supplements/liraglutide-subcutaneous-route/precautions/drg-20073828 – Liraglutide (Subcutaneous Route)
- https://www.medicalnewstoday.com/articles/drugs-saxenda-interactions – Saxenda interactions: Alcohol, supplements, and more
- https://www.novomedlink.com/obesity/products/treatments/saxenda/dosing-administration/using-the-saxenda-pen.html – Saxenda® Instructions for Use
- https://www.medicalnewstoday.com/articles/drugs-saxenda – Saxenda: Cost, use with other therapies, alternatives, and more
- https://www.novomedlink.com/obesity/products/treatments/saxenda/about/how-saxenda-works.html – Saxenda® Mechanism of Action
- https://www.saxenda.com/about-saxenda/how-to-use-the-pen.html – Saxenda® Weight-Loss Pen Instructions | Saxenda® (liraglutide) injection 3mg
- https://www.novomedlink.com/obesity/products/treatments/saxenda/dosing-administration/follow-up-guide.html – Saxenda® (liraglutide) Injection 3 mg Treatment Plan
- https://www.saxenda.com/stay-on-track.html – Stay on Track
- https://www.saxenda.com/support-and-resources/support-hotline.html – Saxenda® Support Program | Saxenda® (liraglutide) injection 3mg
- https://joinfound.com/blog/saxenda-side-effects-how-to-manage-them – Saxenda Side Effects: How to Manage Them | Found
- https://ro.co/weight-loss/saxenda-side-effects/ – Saxenda Side Effects and How to Manage Them
- https://www.saxenda.com/about-saxenda/side-effects.html – Saxenda® Side Effects | Saxenda® (liraglutide) injection 3mg
- https://www.medicalnewstoday.com/articles/drugs-saxenda-side-effects – Saxenda: Side effects and how to manage them
- https://www.novomedlink.com/obesity/products/treatments/saxenda/efficacy-safety/common-adverse-events.html – Saxenda® (liraglutide) Injection 3 mg Adverse Events
- https://www.saxenda.com/about-obesity/health-risks-of-teen-obesity.html – Weight Loss Plateau – Weight Loss Cycle | Saxenda® (liraglutide) injection 3mg
- https://www.fda.gov/drugs/news-events-human-drugs/fda-approves-weight-management-drug-patients-aged-12-and-older – FDA approves weight management drug
- https://www.medicalnewstoday.com/articles/drugs-saxenda-vs-victoza – Saxenda vs. Victoza: What to know about each of these drugs
- https://www.aafp.org/pubs/afp/issues/2016/0715/p161.html – Liraglutide (Saxenda) for Weight Loss
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358074/ – Liraglutide for weight management: a critical review of the evidence
- https://www.ncbi.nlm.nih.gov/books/NBK594336/ – Clinical Review – Liraglutide (Saxenda)
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